Sodium polystyrene sulfonate
Kalexate, Kionex, Polystyrene Sulfonate, Sps (sodium polystyrene sulfonate) is a small molecule pharmaceutical. Sodium polystyrene sulfonate was first approved as Kayexalate on 1982-01-01. It is used to treat hyperkalemia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium polystyrene sulfonate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| KAYEXALATE | Concordia Laboratories | N-011287 DISCN | 1982-01-01 | 1 products, RLD |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperkalemia | HP_0002153 | D006947 | E87.5 |
Agency Specific
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Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperkalemia | D006947 | HP_0002153 | E87.5 | — | 1 | — | 3 | 1 | 5 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | — | — | — | 1 | 1 | 2 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | — | 1 | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 1 | — | 1 |
| Heart rate | D006339 | EFO_0004326 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | — | 4 |
| Rett syndrome | D015518 | Orphanet_778 | F84.2 | — | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | — | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | 1 | — | — | — | 1 |
| Pseudohypoaldosteronism | D011546 | — | — | — | 1 | — | — | — | 1 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 1 | — | — | — | 1 |
| Hyperphosphatemia | D054559 | HP_0002905 | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Autoimmune diseases | D001327 | HP_0002960 | M30-M36 | 2 | — | — | — | — | 2 |
| Cough | D003371 | HP_0012735 | R05 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 1 | 1 |
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 1 | 1 |
| Rehabilitation | D012046 | — | — | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Pediatric obesity | D063766 | — | — | — | — | — | — | 1 | 1 |
| Shoulder impingement syndrome | D019534 | EFO_1001178 | M75.4 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sodium polystyrene sulfonate |
| INN | — |
| Description | Polystyrene sulfonates are a group of medications used to treat high blood potassium. Effects generally take hours to days. They are also used to remove potassium, calcium, and sodium from solutions in technical applications.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 123333-94-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201484 |
| ChEBI ID | — |
| PubChem CID | 75905 |
| DrugBank | DB01344 |
| UNII ID | — |
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Safety
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954 adverse events reported
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